This condition will typically heal within 2 weeks. The first and second degrees of burn injuries usually are treated with the moisturizer, the topical agents, and/or an antimicrobial creams advised by the doctor. This chapter will further discuss the common animal models of burn injury as well as provide researchers with a better understanding of their benefits and limitations for the burn treatment design that is proposed to be clinically applicable to humans.īurn injuries differ in their cause types and severity hence, its treatment can be challenging to be managed. In addition, the selection of the model should consider the anatomical and physiological characteristics of interspecies that reflect the differences in how different types of wounds heal and analytical techniques be applied. Nevertheless, each animal model has advantages and limitations that determine its translational significance for burn treatments. ![]() ![]() For accurately investigating any therapeutic approaches and relevantly translating to the clinical, the utilization of animal models has to be reproducible and as close as possible to burn lesions occurring in humans. The use of these burn animal models is crucial for burn research especially for investigating the properties of new medicines, as it is known that novel treatment strategies should be initially tested at the experimental level before the clinical use. Numerous experimental models have been established and can be applied to address the systemic, cellular, or molecular responses that occur in burn injuries, particularly the development of animal models. The comprehensive study of burn pathophysiology is vital for further improvements of the current treatment strategies. In decades, many important advances have been made for the improvements of the burn care however, more still needs to be undertaken. Further, burn patients also will associate with anxiety, sleep disturbances, social avoidance, depression, and a disruption in activities of daily living after physical rehabilitation. Consequently, there will be an intense inflammatory process and prolonged hypermetabolism, coordinated by hormones, cytokines, and acute phase proteins, which are associated with delayed wound healing process, enormous catabolism, multi-organ failure, and death. For affected large surface area, burns may turn into a systemic problem affecting a various range of organs. Burns are responsible for many pathophysiological changes, resulting in a severe form of trauma that initiates several complications such as an escalation in infection and mortality rates as well as prolonged hospitalization and time of inactivity. ![]() The skin is the largest organ of the body, and its destruction, especially caused by burn injuries, is sufficient to be life threatening.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |